Update: 8:39PM The Sydney Roosters have confirmed their NRL premiership credentials with a convincing 32-12 win over fellow top-four contenders Penrith at the Sydney Football Stadium.
For the Panthers, who had a short turnaround from a thrilling one-point win over Brisbane on Monday night, the emphatic defeat will nonetheless raise doubts about their bona fides against top sides.
This season they have defeated just two sides who went into round 19 inside the top eight and have a tough run into the finals.
In front of a fervent 13,993 strong crowd, Boyd Cordner was superb for the Roosters, running for 202 metres and crashing over for two tries.
Sonny Bill Williams, who did not drink or eat during the day due to his observance of Ramadan, put in a solid 80-minute performance.
The Panthers lacked direction, missing playmakers Peter Wallace and Tyrone Peachey, while half-back Jamie Soward had a poor match, particularly with the boot.
Panthers back-rower Elijah Taylor was sin-binned in the fifth minute for a professional foul and the Roosters made good use of the one-man advantage soon after when Aidan Guerra - playing at centre in a reshuffled backline - went over.
With Roosters number nine Jake Friend off the field with concussion in the ninth minute, stand-in hooker Mitch Aubusson proved himself a capable replacement when he burrowed over from dummy-half.
Soon after, the home side were controversially denied a Mitchell Pearce four-pointer by the video referees when he stole it from the arms of Matt Moylan on the tryline.
However the Roosters did take an 18-0 lead into half-time after Frenchman Remi Casty crashed over for his second try of the year.
The Panthers got back with a sniff through a Bryce Cartwright try in the 58th minute, but a James Maloney penalty goal and a Cordner try nine minutes from full-time sealed the match for the Roosters.
The Panthers scored a late consolation try through James Segeyaro, however the Roosters put an exclamation mark on the win when Cordner got his double.
Aubusson left the field late holding his shoulder following a collision with Maloney.