Abandoned by their father deep in a forest one night, young Hansel and Gretel enter a gingerbread house and are quickly nabbed by the old witch who resides in it. But before she has a chance to eat them, the siblings outsmart her and throw her into the oven.
Throughout the years after the incident, Hansel and Gretel become bounty hunters dedicated to exterminating witches. Their work is relatively easy because for an unknown reason, they are immune to harmful witch spells and curses. Hansel, however, is diabetic and needs to take a regular shot of insulin everyday.
One day, in the German town of Augsburg, Hansel and Gretel prevent Sheriff Berringer from executing Mina, a young woman falsely accused of witchcraft. The town Mayor has hired the siblings to find and rescue several children abducted by witches.
At the same time, Sheriff Berringer hires four trackers for the same mission, hoping to regain the respect of the Mayor. However, all but one of the trackers are killed by the evil sorceress Muriel, who sends the surviving member back to the town tavern to explode as a warning to the siblings and the locals. Hansel and Gretel, with the help of one of the Mayor's men, capture a witch and interrogate her.
They discover that the witches are preparing for the Feast of the Blood Moon, which requires sacrificing 12 children - six boys and six girls, each born on a separate month. When the siblings find out that the witches need one more girl to complete their ritual, Sheriff Berringer refuses to cooperate with them. Suddenly, Muriel and her witches attack the town and abducts the targeted girl before springing their comrade out of jail. Gretel is knocked unconscious throughout the ordeal, but is brought to safety by a local boy named Ben. Hansel grabs a fleeing witch by her broomstick, but is lost in the forest.
The next morning, Hansel is found by Mina, who takes him to a spring to heal his wounds. Meanwhile, Gretel enters the forest to search for her brother, but she is assaulted by Sheriff Berringer and his men, who are arresting her for luring the witches to their town.
Then, from out of nowhere, a troll named Edward charges at the men and mutilates them before bringing Gretel to a waterfall. When asked by Gretel why he saved her, Edward tells her that trolls serve witches before he walks away. Hansel and Gretel reunite at an abandoned cabin, which they discover is not only their childhood home, but also a witch's lair. Muriel appears in front of them, telling them the truth of their past. It is revealed that Hansel and Gretel's mother was a witch named Adrianna. On the night of the Blood Moon, the heart of a Grand White Witch must be pierced to fulfill the evil witches' feast, and Gretel was revealed to be a Grand White Witch herself. To keep the siblings away from the witches, their father left them in the forest, but when he returned to their home, he was hanged by the villagers while Adrianna was burned at the stake. Following this revelation, the siblings battle Muriel before the sorceress stabs Hansel and abducts Gretel.
Hansel wakes up to the sight of Mina, who reveals herself to be a white witch. After Mina uses a spell to bless the siblings' arsenal, Hansel, Mina and Ben head to the top of a hill to disrupt the Feast of the Blood Moon. While Mina mows down dozens of witches with a Gatling gun, Hansel squares off against Muriel's minions and frees the children while Edward defies the sorceress' orders and frees Gretel before he is thrown off the cliff by Muriel. With the ceremony ruined by the sunrise, Muriel and the surviving witches attempt to flee by broomsticks, but the witches are shredded by piano wire traps while Ben shoots Muriel off her broomstick. Hansel, Gretel and Mina follow Muriel's trail to the old gingerbread house. During their confrontation, Mina is fatally stabbed by Muriel. The siblings engage in a grueling fight inside the gingerbread house until they decapitate the sorceress with a shovel.
Hansel and Gretel collect the rest of their reward for rescuing the children before embarking on their next hunt, with Ben and Edward joining them.
Hansel and Gretel: Witch Hunters is an upcoming 2013 action-adventure horror film directed by Tommy Wirkola and filmed in 3-D. It is a continuation to the fairy tale Hansel and Gretel by the Brothers Grimm, starring Jeremy Renner and Gemma Arterton in the titular roles, with Famke Janssen as the leader of a coven of evil witches that they seek out to destroy. The film is released in 3-D and IMAX 3D. It is the first film from MTV Films to be released in IMAX 3D format.